OBJECTIVES To assess the clinical efficacy of clozapine in bipolar disorder and its adverse effect profile. METHODS A literature search with no year and no language restriction was conducted. https://www.selleckchem.com/ The search yielded 3858 articles, with 2453 remaining after duplicate removal; 9 were suitable for the systematic review. From the 9 included studies, 3 (100 patients treated with clozapine and 102 patients treated with other antipsychotics) could be included in a meta-analysis to test clozapine efficacy in the treatment of manic episodes. RESULTS Clozapine's efficacy was similar to other antipsychotics (Mean difference (MD) 0.03 [95%CI 0.86-0.92], p&nbsp;=&nbsp;0.59) in manic episodes. The systematic review also suggested that clozapine is faster at improving symptoms in manic episodes. In addition, two studies included patients with treatment resistant bipolar disorder (TRBD) and showed that clozapine is superior to other treatments for this specific population. Sedation was the most frequent side effect (49.6%), followed by constipation (31.8%) and tachycardia (23.2%). CONCLUSION Clozapine's efficacy was similar to other antipsychotics in manic episodes and is superior to other antipsychotics among TRBD patients. Biological effects have been reproducibly reported in rodents exposed to radiofrequency fields (RF) without significant change of the body temperature. These observations relaunch the controversial question of non-thermal effects of RF. If true, such effects would imply to consider RF energy absorption/interaction in tissues, not as volume-averaged, but locally down to the microscale, which is of potential consequence in particular at frequencies beyond 3&nbsp;GHz. We propose study protocols to explore that question. Desulfurization of sour water was investigated in a combination system of trickling biofilter (BTF) and biofilter (BF) filled with ceramic packing materials. A critical elimination capacity (EC) of 251.93&nbsp;g&nbsp;S m-3 h-1 was obtained for the BTF/BF system during a stepwise increase of sulfide concentration from 10 to 60&nbsp;g&nbsp;S m-3. This stepwise increment of loading rate also led to critical ECs of 176.21 and 478.88&nbsp;g&nbsp;S m-3 h-1 for BTF and BF, respectively. A dynamic model describing biological H2S removal from sour water in the BTF/BF was developed and calibrated by a set of experimental data. The model includes the main processes occurring in the BTF/BF such as mass transfer between phases, diffusion and biological reaction inside the biofilm. The model also considers the intermediate (elemental sulfur) production/consumption and sulfate formation through the different oxidation pathways. The model validation was performed under a starvation period and a dynamic H2S loading period. A sensitivity analysis was carried out to evaluate the relative importance of the key parameters on the performance of the BTF/BF system. Sensitivity analysis showed that the BTF performance is more affected by the parameters related to H2S mass transfer. The assumption that only biological processes are enantioselective introduces challenges in the reliability of enantioselective analysis as a tool for discriminating biotic and abiotic processes in the environmental fate of chiral pollutants. Enantioselectivity does not depend on the nature of the fate process a chiral contaminant undergoes but on the interaction of the chiral contaminant with homochirality inducing external agents (e.g. chiral molecules, macromolecules or surfaces such as enzymes, blood plasma, proteins, chiral co-pollutants, humic acid and soil organominerals). The environmental behavior of a chiral contaminant is difficult to anticipate because the interactions between the chiral contaminants and the homochirality inducing external agents is often complex and strongly influenced by local environment conditions such as pH, redox conditions, organic carbon, organic nitrogen, humic acid, and redox conditions. Furthermore, the use of enantioselective analysis in environmental forensics depend on the adequate separation and accurate identification and quantification of the enantiomers of the chiral contaminant. Matrix effects, instrument effects, inadequate enantioselective separation, and poor quantification techniques introduce uncertainties in the determination of enantiomeric composition. Here we present the weaknesses of this assumption and recommend using enantiomeric fractions as chemical markers of biotransformation with caution. We recommend using stable isotopes, including abiotic controls to determine if enantioselective sorption occurs, and determining stability of enantiomers in solvent or at elevated temperatures to account for confounding factors arising from matrix effects, enantioselective abiotic processes, and enantiomerization due solvent and thermal lability of the chiral analyte, respectively to maintain the integrity of the utility of enantiomeric composition changes as an environmental forensics tool. BACKGROUND Organochlorine pesticides (OCPs) are lipophilic persistent organic pollutants associated with adverse health outcomes. Black women have higher body burdens compared with other U.S. populations and research on their correlates is limited. METHODS Using baseline data from a prospective cohort study of Black women aged 23-35 years from the Detroit, Michigan metropolitan area (enrolled 2010-2012), we examined correlates of plasma concentrations of the following OCPs dichlorodiphenyltrichloroethane (p,p'-DDE), hexachlorobenzene (HCB), oxychlordane, and trans-nonachlor. At enrollment, we collected non-fasting blood samples from 742 participants. We also collected data on demographic, behavioral, dietary, occupational, and medical history factors via self-administered questionnaires, telephone interviews, and in-person clinic visits. We fit linear regression models to calculate percent (%) differences across categories of each correlate and 95% confidence intervals (CIs). RESULTS In models adjusted for al concentrations. Obesity, parity, higher birth order, and longer lactation duration were inversely associated with plasma OCP concentrations. CONCLUSIONS In Black U.S. women of reproductive age, older age was an important correlate of plasma OCP concentrations. Exposure to OCPs earlier in life appears to contribute to current blood concentrations. In addition, tobacco, alcohol, and drinking water may be important sources of exposure.